Skip to main content

How does hyaluronic acid production work? Read the article to find out how the production process influences the quality and safety of fillers.

Hyaluronic acid (HA) is an undisputed player in the world of aesthetic medicine and cosmetology. But how much do we really know about its production process?

This phase is crucial to ensure effective and safe results in aesthetic treatments, where it is used as filler. Indeed, production techniques significantly affect the filler’s purity, consistency and safety.

Therefore, understanding how this process works is crucial, for doctors and patients alike. This is because a high-quality HA offers better results and greatly reduces the risk of side effects.

The aim of this article is precisely to explain what the different production methods are, and how the best hyaluronic acid is produced.

In particular, we will see the following:

How hyaluronic acid production works

Before we get into how hyaluronic acid production works, let’s first understand what kind of substance it is.

HA is a molecule naturally present in the body. Specifically, it is a highly hydrophilic linear polysaccharide, essential for maintaining the hydration of the skin and connective tissues.

The characteristics and properties of hyaluronic acid determine its wide use in aesthetic medicine in the form of fillers. Thanks to its ability to moisturise the skin, fill wrinkles and furrows and provide volume to different areas of the face.

Its biocompatibility determines its low probability of adverse reactions and it guarantees extremely natural and immediate results.

It is precisely here, however, that HA production comes into play. It can take place through various techniques:

  • Extraction from animal tissues: in the past, HA was obtained from animal tissues, in particular cockscombs. This method, however, raised ethical and safety issues.
  • Bacterial biofermentation: in this process, bacterial microorganisms are selected for their ability to synthesise hyaluronic acid. These bacteria are cultivated in tanks by controlled fermentation, converting sugars into hyaluronic acid chains.

Industrial production by bacterial fermentation offers significant advantages in terms of quality, purity and process control.

The best industrial production process for hyaluronic acid

The best industrial production process for hyaluronic acid

Bacterial biofermentation is therefore now widely recognised as the most reliable and safe technique for the industrial production of hyaluronic acid.

Its purity and low probability of side effects make it ideal for a wide range of beauty treatments.

Biofermentation allows precise control over the length of the chains produced. This is essential, since the length of the chains affects the product properties.

Thus, biofermentation guarantees: purity and safety (due to a reduced risk of contamination by impurities or pathogens); reduced risk of allergies; strict quality control.

Lastly, the production of hyaluronic acid by biofermentation is more sustainable than methods involving extraction from animal or plant sources. This technique reduces the environmental impact and respects ethical concerns related to the use of animal sources.

How the best hyaluronic acid filler is produced

Although industrial production by bacterial biofermentation is the best, not all HA produced by this technique are the same. And choosing the best hyaluronic acid fillers makes all the difference in terms of results, durability and tolerability of the injection.

The HA we produce at Foliage by Phitogen is a very pure HA: superior quality; biocompatible and completely reabsorbable; reduced allergenic risk; 100% Made in Italy.

Our exclusive 2CORE technology ensures that Foliage fillers require less chemical crosslinking agents (BDDE). Therefore, they are particularly malleable, homogeneous and compatible with skin tissue.

This innovative technology also allows us to obtain a complete and versatile range of fillers, based on:

  • Their viscosity;
  • Their particle size;
  • The areas to be treated.

The advantage for both doctors and patients is that they can rely on specific products according to the imperfection to be corrected. They also provide a natural, long-lasting anti-ageing effect, with minimized allergenic risk.

Foliage is the result of 20 years' experience of Phitogen Beauty Labs - a leading group in the production of hyaluronic acid-based injectables. Foliage distributes a complete range of high-performing intradermal products.

Via Valtellina, 21
San Benedetto del Tronto (AP)
63074 – Italy

+39 0735 762020